Zane Amenhotep, MD, is a Clinical Professor in the Department of Laboratory Medicine and serves as the Co-Director of the Core Lab Division and Director of the Hematology Clinical Lab Section at Zuckerberg San Francisco General Hospital and Trauma Center.
While we have long known the location of disease-causing mutations in the genome, the discovery of CRISPR finally gave us the ability to correct these typos back to what they should be in healthy patients. While this effort has yielded novel therapies in the clinic, in my own lab I want to look beyond simply correcting DNA typos and instead use genome editing to introduce novel functions into cells for therapeutic purposes.
Examples include:
-Engineering red blood cells to deliver novel protein payloads
My Research Interests are divided into 3 areas of focus:
1. Supportive Care (especially Invasive Fungal Infections) following Hematopoietic Stem Cell Transplantation
2. Transplantation for Severe Combined Immunodeficiency
3. Transplantation for Rare Leukemias (JMML and APL)
