Our lab's goal is to understand the genetic circuits that control human immune cell function in health and disease. We have begun to identify how genetic risk variants for autoimmune diseases disrupt immune cell circuits (Farh and Marson et al., Nature 2015; Simeonov et al., Nature, 2017), and how pathogenic circuits may be targeted with novel therapeutics (Xiao et al., Immunity 2014). My lab has developed new tools for efficient CRISPR genome engineering in primary human T cells (Schumann et al., PNAS 2015; Roth et al., Nature 2018; Nguyen et al. Nature Biotech 2020).
Dr. Ari Molofsky is an Associate Professor at UCSF in the Department of Laboratory Medicine. Trained as a MD/PhD with a clinical specialization in hematopathology, his primary focus is leading a basic research laboratory that works at the intersection of immunology and tissue homeostasis and pathology. Dr. Molofsky uses foundation models to study organ development and remodeling, with a particular focus on stromal - immune niches, with studies that span brain, lung, liver, adipose tissue, skin, and intestine. Dr.
