Rachael Jackman, PhD

Testosterone supplementation increases red blood cell susceptibility to oxidative stress, decreases membrane deformability, and decreases survival after cold storage and transfusion.

Transfusion

Tran J, Jackman RP, Muench MO, Hazegh K, Bean SW, Thomas KA, Fang F, Page G, O'Connor K, Roubinian NH, Anawalt BD, Kanias T

Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice.

Frontiers in immunology

Tran JQ, Muench MO, Gaillard B, Darst O, Tomayko MM, Jackman RP

Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice.

Frontiers in immunology

Jackman RP, Darst O, Gaillard B, Tran JQ, Tomayko MM, Muench MO

Bidirectionality between Cardiometabolic Diseases and COVID-19: Role of Humoral Immunity.

Advances in nutrition (Bethesda, Md.)

Yu EA, Jackman RP, Glesby MJ, Narayan KV

Frequent detection but lack of infectivity of SARS-CoV-2 RNA in pre-symptomatic, infected blood donor plasma.

The Journal of clinical investigation

Saá P, Fink RV, Bakkour S, Jin J, Simmons G, Muench MO, Dawar H, Di Germanio C, Hui AJ, Wright DJ, Krysztof DE, Kleinman SH, Cheung A, Nester T, Kessler DA, Townsend RL, Spencer BR, Kamel H, Vannoy JM, Dave H, Busch MP, Stramer SL, Stone M, Jackman RP, Norris PJ

Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-ß expression by cDCs and monocytes in mice.

Blood advances

Tran JQ, Muench MO, Jackman RP

Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress.

Transfusion

Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D'Alessandro A, Dumont L, Page GP, Kanias T

Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice.

PloS one

Blessinger SA, Tran JQ, Jackman RP, Gilfanova R, Rittenhouse J, Gutierrez AG, Heitman JW, Hazegh K, Kanias T, Muench MO

A small allelic variant in donor class I MHC is sufficient to induce alloantibodies following transfusion of standard or pathogen-reduced platelets in mice.

Vox sanguinis

Jackman RP, Heitman JW, Muench MO

Pathogen reduction with riboflavin and ultraviolet light induces a quasi-apoptotic state in blood leukocytes.

Transfusion

Tran JQ, Muench MO, Heitman JW, Jackman RP

Lack of persistent microchimerism in contemporary transfused trauma patients.

Transfusion

Jackman RP, Utter GH, Lee TH, Montalvo L, Wen L, Chafets D, Rivers RM, Kopko PM, Norris PJ, Busch MP

Potential of Membranes Surrounding the Fetus as Immunoprotective Cell-Carriers for Allogeneic Transplantations.

Transplantation direct

Togarrati PP, Dinglasan N, Yee E, Heitman JW, Jackman RP, Geisberg M, Norris PJ, Bárcena A, Muench MO

Allogeneic major histocompatibility complex antigens are necessary and sufficient for partial tolerance induced by transfusion of pathogen reduced platelets in mice.

Vox sanguinis

Tran JQ, Muench MO, Heitman JW, Jackman RP

Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis.

Lupus science & medicine

Jackman RP, Cruz GI, Nititham J, Triulzi DJ, Barcellos LF, Criswell LA, Norris PJ, Busch MP

Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood.

Transfusion

Jackman RP, Muench MO, Inglis H, Heitman JW, Marschner S, Goodrich RP, Norris PJ

C1q-binding anti-HLA antibodies do not predict platelet transfusion failure in Trial to Reduce Alloimmunization to Platelets study participants.

Transfusion

Jackman RP, Lee JH, Pei R, Bolgiano D, Lebedeva M, Slichter SJ, Norris PJ

Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets.

Transfusion

Muench MO, Heitman JW, Inglis H, Fomin ME, Marschner S, Goodrich RP, Norris PJ, Jackman RP

Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro.

Blood

Danesh A, Inglis HC, Jackman RP, Wu S, Deng X, Muench MO, Heitman JW, Norris PJ

Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment.

Transfusion

Jackman RP, Heitman JW, Marschner S, Goodrich RP, Norris PJ

CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.

Journal of immunology (Baltimore, Md. : 1950)

Jackman RP, Balamuth F, Bottomly K

Mycobacterium tuberculosis/HIV-1 coinfection and disease: role of human leukocyte antigen variation.

The Journal of infectious diseases

Louie LG, Hartogensis WE, Jackman RP, Schultz KA, Zijenah LS, Yiu CH, Nguyen VD, Sohsman MY, Katzenstein DK, Mason PR

Rachael Jackman, PhD

Testosterone supplementation increases red blood cell susceptibility to oxidative stress, decreases membrane deformability, and decreases survival after cold storage and transfusion.

Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice.

Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice.

Bidirectionality between Cardiometabolic Diseases and COVID-19: Role of Humoral Immunity.

Frequent detection but lack of infectivity of SARS-CoV-2 RNA in pre-symptomatic, infected blood donor plasma.

Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-ß expression by cDCs and monocytes in mice.

Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress.

Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice.

A small allelic variant in donor class I MHC is sufficient to induce alloantibodies following transfusion of standard or pathogen-reduced platelets in mice.

Pathogen reduction with riboflavin and ultraviolet light induces a quasi-apoptotic state in blood leukocytes.

Lack of persistent microchimerism in contemporary transfused trauma patients.

Potential of Membranes Surrounding the Fetus as Immunoprotective Cell-Carriers for Allogeneic Transplantations.

Allogeneic major histocompatibility complex antigens are necessary and sufficient for partial tolerance induced by transfusion of pathogen reduced platelets in mice.

Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis.

Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood.

C1q-binding anti-HLA antibodies do not predict platelet transfusion failure in Trial to Reduce Alloimmunization to Platelets study participants.

Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets.

Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro.

Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response.

Immunomodulation in transfused trauma patients.

Immune modulation and lack of alloimmunization following transfusion with pathogen-reduced platelets in mice.

Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants.

Transfusion-associated microchimerism: the hybrid within.

Distinct roles of trauma and transfusion in induction of immune modulation after injury.

Effects of blood sample age at time of separation on measured cytokine concentrations in human plasma.

Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment.

CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.

Mycobacterium tuberculosis/HIV-1 coinfection and disease: role of human leukocyte antigen variation.

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Rachael Jackman, PhD