Soluble Tim-3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression (VIR6P.1165).

Kiera Clayton, Matthew Douglas-Vail, A. Rahman, Karyn Medcalf, Irene Xie, Glen Chew, Ravi Tandon, Marion Lanteri, Philip Norris, Steven Deeks, Lishomwa Ndhlovu, Mario Ostrowski. Soluble Tim-3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression (VIR6P.1165). The Journal of Immunology. 2015 May 1; 194(1_Supplement):149.5-149.5.