Jonathan Esensten, MD, PhD

Associate Adjunct Professor
Laboratory Medicine | Fellowship Role
+1 415 502-3785

Fellowship Role

Publications: 

Development of a robotic cluster for automated and scalable cell therapy manufacturing.

Cytotherapy

Alice Melocchi, Brigitte Schmittlein, Alexis L. Jones, Yasmine Ainane, Ali Rizvi, Darius Chan, Elaine Dickey, Kelsey Pool, Kenny Harsono, Dorothy Szymkiewicz, Umberto Scarfogliero, Varun Bhatia, Amlesh Sivanantham, Nadia Kreciglowa, Allison Hunter, Miguel Gomez, Adrian Tanner, Marco Uboldi, Arpit Batish, Joanna Balcerek, Mariella Kutova-Stoilova, Sreenivasan Paruthiyil, Luis A. Acevedo, Rachel Stadnitskiy, Sabrina Carmichael, Holger Aulbach, Matthew Hewitt, Xavier De Mollerat Du Jeu, Benedetta di Robilant, Federico Parietti, Jonathan H. Esensten

Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.

Science translational medicine

Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano JJ, Lam A, Lee K, Greenland JR, Hellerstein M, Fitch M, Li KW, Esensten JH, Putnam AL, Lares A, Nguyen V, Liu W, Bridges ND, Odim J, Demetris AJ, Levitsky J, Taner T, Feng S

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails.

Nature biotechnology

Shy BR, Vykunta VS, Ha A, Talbot A, Roth TL, Nguyen DN, Pfeifer WG, Chen YY, Blaeschke F, Shifrut E, Vedova S, Mamedov MR, Chung JJ, Li H, Yu R, Wu D, Wolf J, Martin TG, Castro CE, Ye L, Esensten JH, Eyquem J, Marson A

Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience.

Frontiers in immunology

Balcerek J, Shy BR, Putnam AL, Masiello LM, Lares A, Dekovic F, Acevedo L, Lee MR, Nguyen V, Liu W, Paruthiyil S, Xu J, Leinbach AS, Bluestone JA, Tang Q, Esensten JH

The effects of low-dose IL-2 on Treg adoptive cell therapy in patients with Type 1 diabetes.

JCI insight

Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA

Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019.

Open forum infectious diseases

Bainbridge ED, Hsue PY, Esensten JH, Lynch KL, Hendrickson CM, Doernberg SB, Fung M, Chin-Hong P, Di Germanio C, Norris PJ, Simmons G, Glidden DV, Luetkemeyer AF

Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study.

The journal of trauma and acute care surgery

Matthay ZA, Hellmann ZJ, Callcut RA, Matthay EC, Nunez-Garcia B, Duong W, Nahmias J, LaRiccia AK, Spalding MC, Dalavayi SS, Reynolds JK, Lesch H, Wong YM, Chipman AM, Kozar RA, Penaloza L, Mukherjee K, Taghlabi K, Guidry CA, Seng SS, Ratnasekera A, Motameni A, Udekwu P, Madden K, Moore SA, Kirsch J, Goddard J, Haan J, Lightwine K, Ontengco JB, Cullinane DC, Spitzer SA, Kubasiak JC, Gish J, Hazelton JP, Byskosh AZ, Posluszny JA, Ross EE, Park JJ, Robinson B, Abel MK, Fields AT, Esensten JH, Nambiar A, Moore J, Hardman C, Terse P, Luo-Owen X, Stiles A, Pearce B, Tann K, Abdul Jawad K, Ruiz G, Kornblith LZ

Hospital-Based Donor Recruitment and Predonation Serologic Testing for COVID-19 Convalescent Plasma.

American journal of clinical pathology

Balcerek J, Trejo E, Levine K, Couey P, Kornberg ZV, Rogine C, Young C, Li PJ, Shy BR, Taylor JE, Bakhtary S, Friedlander T, Lynch KL, Bern C, Esensten JH

Magnitude and Kinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses and Their Relationship to Disease Severity.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Lynch KL, Whitman JD, Lacanienta NP, Beckerdite EW, Kastner SA, Shy BR, Goldgof GM, Levine AG, Bapat SP, Stramer SL, Esensten JH, Hightower AW, Bern C, Wu AHB

Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Lynch KL, Whitman JD, Lacanienta NP, Beckerdite EW, Kastner SA, Shy BR, Goldgof GM, Levine AG, Bapat SP, Stramer SL, Esensten JH, Hightower AW, Bern C, Wu AHB

Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity.

medRxiv

Kara Lake Lynch, Jeffrey D. Whitman, Noreen P Lacanienta, Erica W Beckerdite, Shannon A Kastner, Brian R Shy, Gregory M Goldgof, Andrew G Levine, Sagar P Bapat, Susan L Stramer, Jonathan H Esensten, Allen W Hightower, Caryn Bern, Alan HB Wu

Effect of combined low dose IL-2 and polyclonal Tregs infusion in Type 1 Diabetes patients.

The Journal of Immunology

Shen Dong, Cody Mowery, Kamir Hiam, Kevan C Herold, Stephen Gitelman, Jonathan Esensten, Weihong Liu, Angela Lares, Vinh Nguyen, Michael Lee, Ashley Leinbach, Jimmie Ye, Qizhi Tang, Jeffrey A Bluestone

253-LB: Effect of Combined Low Dose IL-2 plus Polyclonal Tregs in Type 1 Diabetes Patients.

Diabetes

SHEN DONG, CODY T. MOWERY, KEVAN C. HEROLD, STEPHEN E. GITELMAN, JONATHAN H. ESENSTEN, WEIHONG LIU, ANGELA P. LARES, ASHLEY S. LEINBACH, MICHAEL R. LEE, VINH Q. NGUYEN, AMY L. PUTNAM, JIMMIE YE, QIZHI TANG, JEFFREY BLUESTONE

Development of a large-scale H3.3K27M-specific TCR-transduced T cell manufacturing method for adoptive cell therapy in HLA-A2+ patients with diffuse midline glioma.

Cytotherapy

K. Okada, A. Nguyen, P. Watchmaker, J. Xu, F. Ramsdell, J.H. Esensten, L.H. Butterfield, H. Okada

Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier.

The Journal of allergy and clinical immunology

Esensten JH, Muller YD, Bluestone JA, Tang Q

Reprogramming human T cell function and specificity with non-viral genome targeting.

Nature

Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A

319 Developing a database to track critical parameters for clinical regulatory T cell manufacturing.

Cytotherapy

B.R. Shy, J. Whitman, A.L. Putnam, A. Lares, Q. Tang, J.H. Esensten

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials.

Annual review of pathology

Esensten JH, Bluestone JA, Lim WA

CD28 Costimulation: From Mechanism to Therapy.

Immunity

Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA

Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.

The Journal of pathology

McCleland ML, Soukup TM, Liu SD, Esensten JH, de Sousa e Melo F, Yaylaoglu M, Warming S, Roose-Girma M, Firestein R

Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling.

Proceedings of the National Academy of Sciences of the United States of America

Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA

CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response.

The Journal of experimental medicine

Martínez-Llordella M, Esensten JH, Bailey-Bucktrout SL, Lipsky RH, Marini A, Chen J, Mughal M, Mattson MP, Taub DD, Bluestone JA

microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

de Kouchkovsky D, Esensten JH, Rosenthal WL, Morar MM, Bluestone JA, Jeker LT

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/?B7 family.

Immunological reviews

Bour-Jordan H, Esensten JH, Martinez-Llordella M, Penaranda C, Stumpf M, Bluestone JA

The miR-17-92 cluster is essential for regulatory T cell function in vivo (168.14).

The Journal of Immunology

Lukas Jeker, Dimitri De Kouchkovsky, Jonathan Esensten, Jeffrey Bluestone

Transcriptional profile of CD28 costimulation and Dec1 relevance in T-cell activation (113.14).

The Journal of Immunology

Marc Martinez-Llordella, Jonathan Esensten, Jeffrey Bluestone

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950)

McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM

Plasticity of Human Regulatory T Cells - Characterization of IFN-?-Producing Cells.

Clinical Immunology

Stephanie McClymont, Amy Putnam, Michael Lee, Jonathan Esensten, Weihong Liu, Sven Olek, Udo Baron, Ulrich Hoffmuller, Jeffrey Bluestone, Todd Brusko

Regulatory T cells as therapeutic targets in rheumatoid arthritis.

Nature reviews. Rheumatology

Esensten JH, Wofsy D, Bluestone JA

T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.

Journal of immunology (Baltimore, Md. : 1950)

Esensten JH, Lee MR, Glimcher LH, Bluestone JA

NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone.

Nucleic acids research

Esensten JH, Tsytsykova AV, Lopez-Rodriguez C, Ligeiro FA, Rao A, Goldfeld AE