
Associate Professor
M_Laboratory Medicine
Dr. Ari Molofsky is an Associate Professor at UCSF in the Department of Laboratory Medicine. Trained as a MD/PhD with a clinical specialization in hematopathology, his primary focus is leading a basic research laboratory that works at the intersection of immunology and tissue homeostasis and pathology. Dr. Molofsky uses foundation models to study organ development and remodeling, with a particular focus on stromal - immune niches, with studies that span brain, lung, liver, adipose tissue, skin, and intestine. Dr. Ari Molofsky is also an affiliate member of the UCSF Microbiology and Immunology Department, ImmunoX Program, Liver Center, Pulmonary Research Group, NeuroImmunology Center for Excellence, and the UCSF Diabetes Center.
Publications
0652 The emerging fungal pathogen Candida auris induces IFN? to colonize mammalian hair follicles.
Journal of Investigative Dermatology
Cross-regulation between the nervous system and type 2 immunity.
Science immunology
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313.
Immunity
Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.
The Journal of clinical investigation
The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles.
bioRxiv : the preprint server for biology
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
Science (New York, N.Y.)
Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension.
International journal of molecular sciences
Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading.
bioRxiv : the preprint server for biology
Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.
Frontiers in immunology
Dynamic fibroblast-immune interactions shape wound healing after brain injury.
bioRxiv : the preprint server for biology
Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
bioRxiv : the preprint server for biology
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
bioRxiv : the preprint server for biology
Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice.
The Journal of experimental medicine
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Science (New York, N.Y.)
Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report.
American journal of respiratory cell and molecular biology
Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
Science immunology
ILC2s - development, divergence, dispersal.
Current opinion in immunology
Perivascular stromal cells: Directors of tissue immune niches.
Immunological reviews
Early Life Imprinting of a Th2-Stromal Cell Niche in Skin.
The Journal of Immunology
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
Nature cell biology
Immune outposts in the adventitia: One foot in sea and one on shore.
Current opinion in immunology
Tissue immunity broadcasts near and far.
Nature reviews. Immunology
Adventitial Cuffs: Regional Hubs for Tissue Immunity.
Trends in immunology
Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury.
Frontiers in immunology
Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.
Journal of immunology (Baltimore, Md. : 1950)
Tissue signals imprint ILC2 identity with anticipatory function.
Nature immunology
All along the watchtower: group 2 innate lymphoid cells in allergic responses.
Current opinion in immunology
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
Science (New York, N.Y.)
B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement: Report of 3 Cases in Adult Patients.
The American journal of surgical pathology
A tissue checkpoint regulates type 2 immunity.
Nature immunology
Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells.
European journal of immunology
A worm of one's own: how helminths modulate host adipose tissue function and metabolism.
Trends in parasitology
Peripheral T-Cell Lymphoma, Not Otherwise Specified Presenting as Erythroderma
Pathology Case Reviews
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
The Journal of experimental medicine
Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit.
Critical care medicine
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
Science (New York, N.Y.)
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.
The Journal of experimental medicine
Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death.
Infection and immunity
Differentiate to thrive: lessons from the Legionella pneumophila life cycle.
Molecular microbiology